Hsp70 and Hsp40 chaperones can inhibit self-assembly of polyglutamine proteins into amyloid-like fibrils

The deposition of protein aggregates in neurons is a hallmark of neurodegenerative diseases caused by polyglutamine (polyQ) proteins. We analyzed the effects of the heat shock protein (Hsp) 70 chaperone system on the aggregation of fragments of huntingtin (htt) with expanded polyQ tracts. In vitro,...

Disgrifiad llawn

Manylion Llyfryddiaeth

Cyhoeddwyd yn:	Proc Natl Acad Sci U S A
Prif Awduron:	Muchowski, Paul J., Schaffar, Gregor, Sittler, Annie, Wanker, Erich E., Hayer-Hartl, Manajit K., Hartl, F. Ulrich
Fformat:	Artigo
Iaith:	Inglês
Cyhoeddwyd:	National Academy of Sciences 2000
Pynciau:	Biological Sciences
Mynediad Ar-lein:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC16632/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10859365/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.140202897
Tagiau:	Ychwanegu Tag Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!