Hsp70 and Hsp40 chaperones can inhibit self-assembly of polyglutamine proteins into amyloid-like fibrils

The deposition of protein aggregates in neurons is a hallmark of neurodegenerative diseases caused by polyglutamine (polyQ) proteins. We analyzed the effects of the heat shock protein (Hsp) 70 chaperone system on the aggregation of fragments of huntingtin (htt) with expanded polyQ tracts. In vitro,...

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Bibliographic Details

Published in:	Proc Natl Acad Sci U S A
Main Authors:	Muchowski, Paul J., Schaffar, Gregor, Sittler, Annie, Wanker, Erich E., Hayer-Hartl, Manajit K., Hartl, F. Ulrich
Format:	Artigo
Language:	Inglês
Published:	National Academy of Sciences 2000
Subjects:	Biological Sciences
Online Access:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC16632/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10859365/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.140202897
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