Hepatic lipase expression in macrophages contributes to atherosclerosis in apoE-deficient and LCAT-transgenic mice

Hepatic lipase (HL) has a well-established role in lipoprotein metabolism. However, its role in atherosclerosis is poorly understood. Here we demonstrate that HL deficiency raises the proatherogenic apoB-containing lipoprotein levels in plasma but reduces atherosclerosis in lecithin cholesterol acyl...

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Detalhes bibliográficos
Main Authors: Nong, Zengxuan, González-Navarro, Herminia, Amar, Marcelo, Freeman, Lita, Knapper, Catherine, Neufeld, Edward B., Paigen, Beverly J., Hoyt, Robert F., Fruchart-Najib, Jamila, Santamarina-Fojo, Silvia
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2003
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC166288/
https://ncbi.nlm.nih.gov/pubmed/12897204
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200316484
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