ADENOVIRAL EXPRESSION OF HUMAN LCAT IN NON-HUMAN PRIMATES LEADS TO AN ANTI-ATHEROGENIC LIPOPROTEIN PHENOTYPE BY INCREASING HDL AND LOWERING LDL

Lecithin:cholesterol acyltransferase (LCAT), a key enzyme in HDL metabolism, has been proposed to have atheroprotective properties, by promoting reverse cholesterol transport. Over expression of LCAT in various animal models, however, has led to conflicting results on its overall effect on lipoprote...

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Autores principales: Amar, M.J.A, Shamburek, R.D, Vaisman, B., Knapper, C, Foger, B., Hoyt, R.F., Fojo, S.S, Brewer, B.H., Remaley, T.A.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2009
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3703629/
https://ncbi.nlm.nih.gov/pubmed/19303980
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.metabol.2008.11.019
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