A thumbwheel mechanism for APOA1 activation of LCAT activity in HDL

APOA1 is the most abundant protein in HDL. It modulates interactions that affect HDL’s cardioprotective functions, in part via its activation of the enzyme, LCAT. On nascent discoidal HDL, APOA1 comprises 10 α-helical repeats arranged in an anti-parallel stacked-ring structure that encapsulates a li...

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Detalhes bibliográficos
Publicado no:J Lipid Res
Main Authors: Cooke, Allison L., Morris, Jamie, Melchior, John T., Street, Scott E., Jerome, W. Gray, Huang, Rong, Herr, Andrew B., Smith, Loren E., Segrest, Jere P., Remaley, Alan T., Shah, Amy S., Thompson, Thomas B., Davidson, W. Sean
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Biochemistry and Molecular Biology 2018
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6027914/
https://ncbi.nlm.nih.gov/pubmed/29773713
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M085332
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