A thumbwheel mechanism for APOA1 activation of LCAT activity in HDL

APOA1 is the most abundant protein in HDL. It modulates interactions that affect HDL’s cardioprotective functions, in part via its activation of the enzyme, LCAT. On nascent discoidal HDL, APOA1 comprises 10 α-helical repeats arranged in an anti-parallel stacked-ring structure that encapsulates a li...

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Bibliografske podrobnosti
izdano v:J Lipid Res
Main Authors: Cooke, Allison L., Morris, Jamie, Melchior, John T., Street, Scott E., Jerome, W. Gray, Huang, Rong, Herr, Andrew B., Smith, Loren E., Segrest, Jere P., Remaley, Alan T., Shah, Amy S., Thompson, Thomas B., Davidson, W. Sean
Format: Artigo
Jezik:Inglês
Izdano: The American Society for Biochemistry and Molecular Biology 2018
Teme:
Research Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6027914/
https://ncbi.nlm.nih.gov/pubmed/29773713
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M085332
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