A thumbwheel mechanism for APOA1 activation of LCAT activity in HDL

APOA1 is the most abundant protein in HDL. It modulates interactions that affect HDL’s cardioprotective functions, in part via its activation of the enzyme, LCAT. On nascent discoidal HDL, APOA1 comprises 10 α-helical repeats arranged in an anti-parallel stacked-ring structure that encapsulates a li...

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Dades bibliogràfiques
Publicat a:J Lipid Res
Autors principals: Cooke, Allison L., Morris, Jamie, Melchior, John T., Street, Scott E., Jerome, W. Gray, Huang, Rong, Herr, Andrew B., Smith, Loren E., Segrest, Jere P., Remaley, Alan T., Shah, Amy S., Thompson, Thomas B., Davidson, W. Sean
Format: Artigo
Idioma:Inglês
Publicat: The American Society for Biochemistry and Molecular Biology 2018
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6027914/
https://ncbi.nlm.nih.gov/pubmed/29773713
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M085332
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