A thumbwheel mechanism for APOA1 activation of LCAT activity in HDL

APOA1 is the most abundant protein in HDL. It modulates interactions that affect HDL’s cardioprotective functions, in part via its activation of the enzyme, LCAT. On nascent discoidal HDL, APOA1 comprises 10 α-helical repeats arranged in an anti-parallel stacked-ring structure that encapsulates a li...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Lipid Res
Prif Awduron: Cooke, Allison L., Morris, Jamie, Melchior, John T., Street, Scott E., Jerome, W. Gray, Huang, Rong, Herr, Andrew B., Smith, Loren E., Segrest, Jere P., Remaley, Alan T., Shah, Amy S., Thompson, Thomas B., Davidson, W. Sean
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: The American Society for Biochemistry and Molecular Biology 2018
Pynciau:
Research Articles
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6027914/
https://ncbi.nlm.nih.gov/pubmed/29773713
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M085332
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