Unique amino acids cluster for switching from the dehydrogenase to oxidase form of xanthine oxidoreductase

In mammals, xanthine oxidoreductase is synthesized as a dehydrogenase (XDH) but can be readily converted to its oxidase form (XO) either by proteolysis or modification of cysteine residues. The crystal structures of bovine milk XDH and XO demonstrated that atoms in the highly charged active-site loo...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Kuwabara, Yoshimitsu, Nishino, Tomoko, Okamoto, Ken, Matsumura, Tomohiro, Eger, Bryan T., Pai, Emil F., Nishino, Takeshi
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 2003
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC166201/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12817083/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.1431485100
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