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Unique amino acids cluster for switching from the dehydrogenase to oxidase form of xanthine oxidoreductase
In mammals, xanthine oxidoreductase is synthesized as a dehydrogenase (XDH) but can be readily converted to its oxidase form (XO) either by proteolysis or modification of cysteine residues. The crystal structures of bovine milk XDH and XO demonstrated that atoms in the highly charged active-site loo...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2003
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC166201/ https://ncbi.nlm.nih.gov/pubmed/12817083 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1431485100 |
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