Unique amino acids cluster for switching from the dehydrogenase to oxidase form of xanthine oxidoreductase

In mammals, xanthine oxidoreductase is synthesized as a dehydrogenase (XDH) but can be readily converted to its oxidase form (XO) either by proteolysis or modification of cysteine residues. The crystal structures of bovine milk XDH and XO demonstrated that atoms in the highly charged active-site loo...

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Bibliographic Details
Main Authors: Kuwabara, Yoshimitsu, Nishino, Tomoko, Okamoto, Ken, Matsumura, Tomohiro, Eger, Bryan T., Pai, Emil F., Nishino, Takeshi
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2003
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC166201/
https://ncbi.nlm.nih.gov/pubmed/12817083
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1431485100
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