Unique amino acids cluster for switching from the dehydrogenase to oxidase form of xanthine oxidoreductase
In mammals, xanthine oxidoreductase is synthesized as a dehydrogenase (XDH) but can be readily converted to its oxidase form (XO) either by proteolysis or modification of cysteine residues. The crystal structures of bovine milk XDH and XO demonstrated that atoms in the highly charged active-site loo...
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| Опубликовано в:: | Proc Natl Acad Sci U S A |
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| Главные авторы: | , , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
National Academy of Sciences
2003
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC166201/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12817083/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.1431485100 |
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