Unique amino acids cluster for switching from the dehydrogenase to oxidase form of xanthine oxidoreductase
In mammals, xanthine oxidoreductase is synthesized as a dehydrogenase (XDH) but can be readily converted to its oxidase form (XO) either by proteolysis or modification of cysteine residues. The crystal structures of bovine milk XDH and XO demonstrated that atoms in the highly charged active-site loo...
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| Publicat a: | Proc Natl Acad Sci U S A |
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| Autors principals: | , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
National Academy of Sciences
2003
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC166201/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12817083/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.1431485100 |
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