Adrenalectomy stimulates hypothalamic proopiomelanocortin expression but does not correct diet-induced obesity

BACKGROUND: Elevated glucocorticoid production and reduced hypothalamic POMC mRNA can cause obese phenotypes. Conversely, adrenalectomy can reverse obese phenotypes caused by the absence of leptin, a model in which glucocorticoid production is elevated. Adrenalectomy also increases hypothalamic POMC...

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Bibliografski detalji
Glavni autori: Makimura, Hideo, Mizuno, Tooru M, Beasley, Joe, Silverstein, Jeffrey H, Mobbs, Charles V
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2003
Teme:
Research Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC165436/
https://ncbi.nlm.nih.gov/pubmed/12795810
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1472-6793-3-4
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