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Role of glucocorticoids in mediating effects of fasting and diabetes on hypothalamic gene expression

BACKGROUND: Fasting and diabetes are characterized by elevated glucocorticoids and reduced insulin, leptin, elevated hypothalamic AGRP and NPY mRNA, and reduced hypothalamic POMC mRNA. Although leptin replacement can reverse changes in hypothalamic gene expression associated with fasting and diabete...

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Detalhes bibliográficos
Main Authors: Makimura, Hideo, Mizuno, Tooru M, Isoda, Fumiko, Beasley, Joe, Silverstein, Jeffrey H, Mobbs, Charles V
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2003
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC179893/
https://ncbi.nlm.nih.gov/pubmed/12848900
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1472-6793-3-5
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