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Reducing hypothalamic AGRP by RNA interference increases metabolic rate and decreases body weight without influencing food intake

BACKGROUND: Several lines of evidence strongly suggest that agouti-related peptide (AGRP) plays a key role in the regulation of metabolic function but ablation of the AGRP gene has no apparent effect on metabolic function. Since specific pharmacological antagonists of AGRP do not presently exist, we...

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Detalhes bibliográficos
Main Authors: Makimura, Hideo, Mizuno, Tooru M, Mastaitis, Jason W, Agami, Reuven, Mobbs, Charles V
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2002
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC134599/
https://ncbi.nlm.nih.gov/pubmed/12423556
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2202-3-18
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