Cooperation of Cytokine Signaling with Chimeric Transcription Factors in Leukemogenesis: PML-Retinoic Acid Receptor Alpha Blocks Growth Factor-Mediated Differentiation

We utilized a mouse model of acute promyelocytic leukemia (APL) to investigate how aberrant activation of cytokine signaling pathways interacts with chimeric transcription factors to generate acute myeloid leukemia. Expression in mice of the APL-associated fusion, PML-RARA, initially has only modest...

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Главные авторы: Phan, Vernon T., Shultz, David B., Truong, Bao-Tran H., Blake, Timothy J., Brown, Anna L., Gonda, Thomas J., Beau, Michelle M. Le, Kogan, Scott C.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Microbiology 2003
Предметы:
Cell Growth and Development
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC164846/
https://ncbi.nlm.nih.gov/pubmed/12808098
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.23.13.4573-4585.2003
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