Cooperation of Cytokine Signaling with Chimeric Transcription Factors in Leukemogenesis: PML-Retinoic Acid Receptor Alpha Blocks Growth Factor-Mediated Differentiation

We utilized a mouse model of acute promyelocytic leukemia (APL) to investigate how aberrant activation of cytokine signaling pathways interacts with chimeric transcription factors to generate acute myeloid leukemia. Expression in mice of the APL-associated fusion, PML-RARA, initially has only modest...

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Detalhes bibliográficos
Main Authors: Phan, Vernon T., Shultz, David B., Truong, Bao-Tran H., Blake, Timothy J., Brown, Anna L., Gonda, Thomas J., Beau, Michelle M. Le, Kogan, Scott C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2003
Assuntos:
Cell Growth and Development
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC164846/
https://ncbi.nlm.nih.gov/pubmed/12808098
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.23.13.4573-4585.2003
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