B1 oligomerization regulates PML nuclear body biogenesis and leukemogenesis

ProMyelocyticLeukemia (PML) protein can polymerize into a mega-Dalton nuclear assembly of 0.1–2 μm in diameter. The mechanism of PML nuclear body biogenesis remains elusive. Here, PML(RBCC) is successfully purified. The gel filtration and ultracentrifugation analysis suggest a previously unrecognize...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Nat Commun
Prif Awduron: Li, Yuwen, Ma, Xiaodan, Chen, Zhiming, Wu, Haiyan, Wang, Pengran, Wu, Wenyu, Cheng, Nuo, Zeng, Longhui, Zhang, Hao, Cai, Xun, Chen, Sai-Juan, Chen, Zhu, Meng, Guoyu
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group UK 2019
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6706441/
https://ncbi.nlm.nih.gov/pubmed/31439836
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-11746-0
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