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B1 oligomerization regulates PML nuclear body biogenesis and leukemogenesis
ProMyelocyticLeukemia (PML) protein can polymerize into a mega-Dalton nuclear assembly of 0.1–2 μm in diameter. The mechanism of PML nuclear body biogenesis remains elusive. Here, PML(RBCC) is successfully purified. The gel filtration and ultracentrifugation analysis suggest a previously unrecognize...
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| 發表在: | Nat Commun |
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| Main Authors: | , , , , , , , , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Nature Publishing Group UK
2019
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6706441/ https://ncbi.nlm.nih.gov/pubmed/31439836 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-11746-0 |
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