Molecular Distinction between Pathogenic and Infectious Properties of the Prion Protein

Tg(PG14) mice express a prion protein (PrP) with a nine-octapeptide insertion associated with a human familial prion disease. These animals spontaneously develop a fatal neurodegenerative disorder characterized by ataxia, neuronal apoptosis, and accumulation in the brain of an aggregated and weakly...

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Detalhes bibliográficos
Main Authors: Chiesa, Roberto, Piccardo, Pedro, Quaglio, Elena, Drisaldi, Bettina, Si-Hoe, San Ling, Takao, Masaki, Ghetti, Bernardino, Harris, David A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2003
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC164780/
https://ncbi.nlm.nih.gov/pubmed/12805461
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.77.13.7611-7622.2003
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