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Unusual origins of isotope effects in enzyme-catalysed reactions

High hydrostatic pressure is a neglected tool for probing the origins of isotope effects. In chemical reactions, normal primary deuterium isotope effects (DIEs) arising solely from differences in zero point energies are unaffected by pressure; but some anomalous isotope effects in which hydrogen tun...

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Autore principale: Northrop, Dexter B
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Royal Society 2006
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1647306/
https://ncbi.nlm.nih.gov/pubmed/16873122
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rstb.2006.1875
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