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Dynamical origins of heat capacity changes in enzyme-catalysed reactions

Heat capacity changes are emerging as essential for explaining the temperature dependence of enzyme-catalysed reaction rates. This has important implications for enzyme kinetics, thermoadaptation and evolution, but the physical basis of these heat capacity changes is unknown. Here we show by a combi...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: van der Kamp, Marc W., Prentice, Erica J., Kraakman, Kirsty L., Connolly, Michael, Mulholland, Adrian J., Arcus, Vickery L.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5862990/
https://ncbi.nlm.nih.gov/pubmed/29563521
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-03597-y
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