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Suppressed catalytic activity of base excision repair enzymes on rotationally positioned uracil in nucleosomes

The majority of DNA in eukaryotic cells exists in the highly condensed structural hierarchy of chromatin, which presents a challenge to DNA repair enzymes in that recognition, incision, and restoration of the original sequence at most sites must take place within these structural constraints. To tes...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Beard, Brian C., Wilson, Samuel H., Smerdon, Michael J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2003
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC164609/
https://ncbi.nlm.nih.gov/pubmed/12799467
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1330328100
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