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Rotational dynamics of DNA on the nucleosome surface markedly impact accessibility to a DNA repair enzyme

Histones play a crucial role in the organization of DNA in the nucleus, but their presence can prevent interactions with DNA binding proteins responsible for repair of DNA damage. Uracil is an abundant mutagenic lesion recognized by uracil DNA glycosylase (UDG) in the first step of base excision rep...

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Detalhes bibliográficos
Main Authors: Hinz, John M., Rodriguez, Yesenia, Smerdon, Michael J.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2842065/
https://ncbi.nlm.nih.gov/pubmed/20176960
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0914443107
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