The Structural Location of DNA Lesions in Nucleosome Core Particles Determines Accessibility by Base Excision Repair Enzymes

Packaging of DNA into chromatin affects accessibility of DNA regulatory factors involved in transcription, replication, and repair. Evidence suggests that even in the nucleosome core particle (NCP), accessibility to damaged DNA is hindered by the presence of the histone octamer. Base excision repair...

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Bibliographic Details
Main Authors: Rodriguez, Yesenia, Smerdon, Michael J.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2013
Subjects:
DNA and Chromosomes
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3650422/
https://ncbi.nlm.nih.gov/pubmed/23543741
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.441444
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