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Suppressed catalytic activity of base excision repair enzymes on rotationally positioned uracil in nucleosomes

The majority of DNA in eukaryotic cells exists in the highly condensed structural hierarchy of chromatin, which presents a challenge to DNA repair enzymes in that recognition, incision, and restoration of the original sequence at most sites must take place within these structural constraints. To tes...

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Bibliografske podrobnosti
Main Authors: Beard, Brian C., Wilson, Samuel H., Smerdon, Michael J.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2003
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC164609/
https://ncbi.nlm.nih.gov/pubmed/12799467
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1330328100
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