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Suppressed catalytic activity of base excision repair enzymes on rotationally positioned uracil in nucleosomes
The majority of DNA in eukaryotic cells exists in the highly condensed structural hierarchy of chromatin, which presents a challenge to DNA repair enzymes in that recognition, incision, and restoration of the original sequence at most sites must take place within these structural constraints. To tes...
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| Main Authors: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
2003
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC164609/ https://ncbi.nlm.nih.gov/pubmed/12799467 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1330328100 |
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