Fatty acid synthesis is essential in embryonic development: Fatty acid synthase null mutants and most of the heterozygotes die in utero

In animals, including humans, the source of long-chain saturated fatty acids is de novo synthesis, which is mediated by fatty acid synthase (FAS), ingested food, or both. To understand the importance of de novo fatty acid synthesis, we generated FAS knockout mice. The heterozygous FAS mutants (Fasn(...

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Bibliografiset tiedot
Päätekijät: Chirala, Subrahmanyam S., Chang, Hua, Matzuk, Martin, Abu-Elheiga, Lutfi, Mao, Jianqiang, Mahon, Kathleen, Finegold, Milton, Wakil, Salih J.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: National Academy of Sciences 2003
Aiheet:
Biological Sciences
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC164451/
https://ncbi.nlm.nih.gov/pubmed/12738878
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0931394100
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