Fatty acid synthesis is essential in embryonic development: Fatty acid synthase null mutants and most of the heterozygotes die in utero

In animals, including humans, the source of long-chain saturated fatty acids is de novo synthesis, which is mediated by fatty acid synthase (FAS), ingested food, or both. To understand the importance of de novo fatty acid synthesis, we generated FAS knockout mice. The heterozygous FAS mutants (Fasn(...

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Bibliografski detalji

Izdano u:	Proc Natl Acad Sci U S A
Glavni autori:	Chirala, Subrahmanyam S., Chang, Hua, Matzuk, Martin, Abu-Elheiga, Lutfi, Mao, Jianqiang, Mahon, Kathleen, Finegold, Milton, Wakil, Salih J.
Format:	Artigo
Jezik:	Inglês
Izdano:	National Academy of Sciences 2003
Teme:	Biological Sciences
Online pristup:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC164451/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12738878/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0931394100
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