Recruitment of the Nucleotide Excision Repair Endonuclease XPG to Sites of UV-Induced DNA Damage Depends on Functional TFIIH

The structure-specific endonuclease XPG is an indispensable core protein of the nucleotide excision repair (NER) machinery. XPG cleaves the DNA strand at the 3′ side of the DNA damage. XPG binding stabilizes the NER preincision complex and is essential for the 5′ incision by the ERCC1/XPF endonuclea...

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Main Authors: Zotter, Angelika, Luijsterburg, Martijn S., Warmerdam, Daniël O., Ibrahim, Shehu, Nigg, Alex, van Cappellen, Wiggert A., Hoeijmakers, Jan H. J., van Driel, Roel, Vermeulen, Wim, Houtsmuller, Adriaan B.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2006
Fag:
Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1636808/
https://ncbi.nlm.nih.gov/pubmed/17000769
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00695-06
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