Hormonal Control of Androgen Receptor Function through SIRT1

The NAD-dependent histone deacetylase Sir2 plays a key role in connecting cellular metabolism with gene silencing and aging. The androgen receptor (AR) is a ligand-regulated modular nuclear receptor governing prostate cancer cellular proliferation, differentiation, and apoptosis in response to andro...

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Autores principales: Fu, Maofu, Liu, Manran, Sauve, Anthony A., Jiao, Xuanmao, Zhang, Xueping, Wu, Xiaofang, Powell, Michael J., Yang, Tianle, Gu, Wei, Avantaggiati, Maria Laura, Pattabiraman, Nagarajan, Pestell, Timothy G., Wang, Fang, Quong, Andrew A., Wang, Chenguang, Pestell, Richard G.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2006
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Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1636736/
https://ncbi.nlm.nih.gov/pubmed/16923962
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00289-06
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