Functional validation of the anaplastic lymphoma kinase signature identifies CEBPB and Bcl2A1 as critical target genes

Anaplastic large cell lymphomas (ALCLs) represent a subset of lymphomas in which the anaplastic lymphoma kinase (ALK) gene is frequently fused to the nucleophosmin (NPM) gene. We previously demonstrated that the constitutive phosphorylation of ALK chimeric proteins is sufficient to induce cellular t...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Piva, Roberto, Pellegrino, Elisa, Mattioli, Michela, Agnelli, Luca, Lombardi, Luigia, Boccalatte, Francesco, Costa, Giulia, Ruggeri, Bruce A., Cheng, Mangeng, Chiarle, Roberto, Palestro, Giorgio, Neri, Antonino, Inghirami, Giorgio
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: American Society for Clinical Investigation 2006
Θέματα:
Research Article
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1636692/
https://ncbi.nlm.nih.gov/pubmed/17111047
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI29401
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