Functional validation of the anaplastic lymphoma kinase signature identifies CEBPB and Bcl2A1 as critical target genes

Anaplastic large cell lymphomas (ALCLs) represent a subset of lymphomas in which the anaplastic lymphoma kinase (ALK) gene is frequently fused to the nucleophosmin (NPM) gene. We previously demonstrated that the constitutive phosphorylation of ALK chimeric proteins is sufficient to induce cellular t...

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Detalhes bibliográficos
Main Authors: Piva, Roberto, Pellegrino, Elisa, Mattioli, Michela, Agnelli, Luca, Lombardi, Luigia, Boccalatte, Francesco, Costa, Giulia, Ruggeri, Bruce A., Cheng, Mangeng, Chiarle, Roberto, Palestro, Giorgio, Neri, Antonino, Inghirami, Giorgio
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2006
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1636692/
https://ncbi.nlm.nih.gov/pubmed/17111047
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI29401
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