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In Vivo Interference with Skp1 Function Leads to Genetic Instability and Neoplastic Transformation
Skp1 is involved in a variety of crucial cellular functions, among which the best understood is the formation together with Cul1 of Skp1-cullin-F-box protein ubiquitin ligases. To investigate the role of Skp1, we generated transgenic (Tg) mice expressing a Cul1 deletion mutant (Cul1-N252) able to se...
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| Hauptverfasser: | , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Society for Microbiology
2002
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC134052/ https://ncbi.nlm.nih.gov/pubmed/12417738 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.22.23.8375-8387.2002 |
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