In Vivo Interference with Skp1 Function Leads to Genetic Instability and Neoplastic Transformation

Skp1 is involved in a variety of crucial cellular functions, among which the best understood is the formation together with Cul1 of Skp1-cullin-F-box protein ubiquitin ligases. To investigate the role of Skp1, we generated transgenic (Tg) mice expressing a Cul1 deletion mutant (Cul1-N252) able to se...

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Detalhes bibliográficos
Main Authors: Piva, Roberto, Liu, Jian, Chiarle, Roberto, Podda, Antonello, Pagano, Michele, Inghirami, Giorgio
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2002
Assuntos:
Cell Growth and Development
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC134052/
https://ncbi.nlm.nih.gov/pubmed/12417738
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.22.23.8375-8387.2002
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