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Activated oncogenes promote and cooperate with chromosomal instability for neoplastic transformation
Most cancer cells are aneuploid. The chromosomal instability hypothesis contends that aneuploidy is the catalyst for transformation, whereas the gene mutation hypothesis asserts that cancer is driven by mutations to proto-oncogenes and tumor-suppressor genes, with the aneuploidy a side effect of tum...
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| Hlavní autoři: | , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Cold Spring Harbor Laboratory Press
2004
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC420357/ https://ncbi.nlm.nih.gov/pubmed/15175263 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1165204 |
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