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Loss of anchorage in checkpoint-deficient cells increases genomic instability and promotes oncogenic transformation
Mammalian cells generally require both mitogens and anchorage signals in order to proliferate. An important characteristic of many tumour cells is that they have lost this anchorage-dependent cell-cycle checkpoint, allowing them to proliferate without signals provided by their normal microenvironmen...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Company of Biologists
2009
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2871077/ https://ncbi.nlm.nih.gov/pubmed/19690052 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.047126 |
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