Fhit Deficiency-Induced Global Genome Instability Promotes Mutation and Clonal Expansion

Loss of Fhit expression, encoded at chromosome fragile site FRA3B, leads to increased replication stress, genome instability and accumulation of genetic alterations. We have proposed that Fhit is a genome ‘caretaker’ whose loss initiates genome instability in preneoplastic lesions. We have character...

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Autors principals: Miuma, Satoshi, Saldivar, Joshua C., Karras, Jenna R., Waters, Catherine E., Paisie, Carolyn A., Wang, Yao, Jin, Victor, Sun, Jin, Druck, Teresa, Zhang, Jie, Huebner, Kay
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2013
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3828255/
https://ncbi.nlm.nih.gov/pubmed/24244712
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0080730
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