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Polypyrimidine Tract Binding Protein Blocks the 5′ Splice Site Dependent Assembly of U2AF and the Prespliceosomal E Complex

Polypyrimidine tract binding protein (PTB) represses the splicing of many alternatively spliced exons. This repression can sometimes involve the direct occlusion of splice sites by PTB. We show here that PTB prevents splicing of the c-src N1 exon to downstream exon 4 by a different mechanism. PTB do...

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Hlavní autoři: Sharma, Shalini, Falick, Arnold M., Black, Douglas L.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2005
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1635971/
https://ncbi.nlm.nih.gov/pubmed/16109373
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2005.07.014
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