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U1 snRNA Directly Interacts with Polypyrimidine Tract Binding Protein During Splicing Repression

Splicing of the c-src N1 exon is repressed by the polypyrimidine tract binding protein (PTB or PTBP1). During exon repression, the U1 snRNP binds properly to the N1 exon 5′ splice site but is made inactive by the presence of PTB. Examining the patterns of nuclease protection at this 5′ splice site,...

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Detalhes bibliográficos
Main Authors: Sharma, Shalini, Maris, Christophe, Allain, Frédéric H-T, Black, Douglas L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3931528/
https://ncbi.nlm.nih.gov/pubmed/21362553
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2011.02.012
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