Peptide Deformylase Inhibitors as Potent Antimycobacterial Agents

Peptide deformylase (PDF) catalyzes the hydrolytic removal of the N-terminal formyl group from nascent proteins. This is an essential step in bacterial protein synthesis, making PDF an attractive target for antibacterial drug development. Essentiality of the def gene, encoding PDF from Mycobacterium...

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Detalles Bibliográficos
Autores principales: Teo, Jeanette W. P., Thayalan, Pamela, Beer, David, Yap, Amelia S. L., Nanjundappa, Mahesh, Ngew, Xinyi, Duraiswamy, Jeyaraj, Liung, Sarah, Dartois, Veronique, Schreiber, Mark, Hasan, Samiul , Cynamon, Michael, Ryder, Neil S., Yang, Xia, Weidmann, Beat, Bracken, Kathryn , Dick, Thomas, Mukherjee, Kakoli
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2006
Materias:
Susceptibility
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1635232/
https://ncbi.nlm.nih.gov/pubmed/16966397
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00555-06
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