Peptide Deformylase Inhibitors as Potent Antimycobacterial Agents

Peptide deformylase (PDF) catalyzes the hydrolytic removal of the N-terminal formyl group from nascent proteins. This is an essential step in bacterial protein synthesis, making PDF an attractive target for antibacterial drug development. Essentiality of the def gene, encoding PDF from Mycobacterium...

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Hlavní autoři: Teo, Jeanette W. P., Thayalan, Pamela, Beer, David, Yap, Amelia S. L., Nanjundappa, Mahesh, Ngew, Xinyi, Duraiswamy, Jeyaraj, Liung, Sarah, Dartois, Veronique, Schreiber, Mark, Hasan, Samiul , Cynamon, Michael, Ryder, Neil S., Yang, Xia, Weidmann, Beat, Bracken, Kathryn , Dick, Thomas, Mukherjee, Kakoli
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2006
Témata:
Susceptibility
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1635232/
https://ncbi.nlm.nih.gov/pubmed/16966397
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00555-06
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