Peptide Deformylase Inhibitors as Potent Antimycobacterial Agents

Peptide deformylase (PDF) catalyzes the hydrolytic removal of the N-terminal formyl group from nascent proteins. This is an essential step in bacterial protein synthesis, making PDF an attractive target for antibacterial drug development. Essentiality of the def gene, encoding PDF from Mycobacterium...

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Autori principali: Teo, Jeanette W. P., Thayalan, Pamela, Beer, David, Yap, Amelia S. L., Nanjundappa, Mahesh, Ngew, Xinyi, Duraiswamy, Jeyaraj, Liung, Sarah, Dartois, Veronique, Schreiber, Mark, Hasan, Samiul , Cynamon, Michael, Ryder, Neil S., Yang, Xia, Weidmann, Beat, Bracken, Kathryn , Dick, Thomas, Mukherjee, Kakoli
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2006
Soggetti:
Susceptibility
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1635232/
https://ncbi.nlm.nih.gov/pubmed/16966397
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00555-06
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