Peptide Deformylase Inhibitors as Potent Antimycobacterial Agents

Peptide deformylase (PDF) catalyzes the hydrolytic removal of the N-terminal formyl group from nascent proteins. This is an essential step in bacterial protein synthesis, making PDF an attractive target for antibacterial drug development. Essentiality of the def gene, encoding PDF from Mycobacterium...

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Detalhes bibliográficos
Main Authors: Teo, Jeanette W. P., Thayalan, Pamela, Beer, David, Yap, Amelia S. L., Nanjundappa, Mahesh, Ngew, Xinyi, Duraiswamy, Jeyaraj, Liung, Sarah, Dartois, Veronique, Schreiber, Mark, Hasan, Samiul , Cynamon, Michael, Ryder, Neil S., Yang, Xia, Weidmann, Beat, Bracken, Kathryn , Dick, Thomas, Mukherjee, Kakoli
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2006
Assuntos:
Susceptibility
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1635232/
https://ncbi.nlm.nih.gov/pubmed/16966397
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00555-06
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