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Peptide Deformylase Inhibitors as Potent Antimycobacterial Agents
Peptide deformylase (PDF) catalyzes the hydrolytic removal of the N-terminal formyl group from nascent proteins. This is an essential step in bacterial protein synthesis, making PDF an attractive target for antibacterial drug development. Essentiality of the def gene, encoding PDF from Mycobacterium...
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| Autori principali: | , , , , , , , , , , , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society for Microbiology
2006
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1635232/ https://ncbi.nlm.nih.gov/pubmed/16966397 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00555-06 |
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