Smad4 is dispensable for normal pancreas development yet critical in progression and tumor biology of pancreas cancer

SMAD4 is inactivated in the majority of pancreatic ductal adenocarcinomas (PDAC) with concurrent mutational inactivation of the INK4A/ARF tumor suppressor locus and activation of the KRAS oncogene. Here, using genetically engineered mice, we determined the impact of SMAD4 deficiency on the developme...

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Detalhes bibliográficos
Main Authors: Bardeesy, Nabeel, Cheng, Kuang-hung, Berger, Justin H., Chu, Gerald C., Pahler, Jessica, Olson, Peter, Hezel, Aram F., Horner, James, Lauwers, Gregory Y., Hanahan, Douglas, DePinho, Ronald A.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2006
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1635148/
https://ncbi.nlm.nih.gov/pubmed/17114584
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1478706
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