Antiviral effect in human cytomegalovirus-infected cells, pharmacokinetics, and intravitreal toxicology in rabbits of acyclovir diphosphate dimyristoylglycerol.

Acyclovir diphosphate dimyristoylglycerol (ACVDP-DG) is a lipid prodrug which is active against ACV-resistant strains of herpes simplex virus because of its intracellular metabolism to ACV monophosphate. In human cytomegalovirus (HCMV)-infected MRC-5 cells, ACVDP-DG was ninefold more active than ACV...

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Publicado en:	Antimicrob Agents Chemother
Autores principales:	Shakiba, S, Freeman, W R, Flores-Aguilar, M, Munguia, D, Tatebayashi, M, Besen, G, Amani, R, Wiley, C A, Vuong, C, Aldern, K A
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	American Society for Microbiology (ASM) 1995
Materias:	Research Article
Acceso en línea:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC162748/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7574537/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.39.6.1383
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