Greatly enhanced inhibition of human immunodeficiency virus type 1 replication in CEM and HT4-6C cells by 3'-deoxythymidine diphosphate dimyristoylglycerol, a lipid prodrug of 3'-deoxythymidine.

3'-Deoxythymidine (3dT) is a weakly active dideoxynucleoside in human immunodeficiency virus (HIV)-infected cells because of its slow phosphorylation by cellular thymidine kinase. 3dT diphosphate dimyristoylglycerol (3dTDP-DMG), a phospholipid prodrug, was synthesized and found in vitro to be 18- to...

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Veröffentlicht in:	Antimicrob Agents Chemother
Hauptverfasser:	Hostetler, K Y, Richman, D D, Carson, D A, Stuhmiller, L M, van Wijk, G M, van den Bosch, H
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 1992
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC192430/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1416896/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.36.9.2025
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