Antiviral effect in human cytomegalovirus-infected cells, pharmacokinetics, and intravitreal toxicology in rabbits of acyclovir diphosphate dimyristoylglycerol.

Acyclovir diphosphate dimyristoylglycerol (ACVDP-DG) is a lipid prodrug which is active against ACV-resistant strains of herpes simplex virus because of its intracellular metabolism to ACV monophosphate. In human cytomegalovirus (HCMV)-infected MRC-5 cells, ACVDP-DG was ninefold more active than ACV...

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Bibliografski detalji
Glavni autori: Shakiba, S, Freeman, W R, Flores-Aguilar, M, Munguia, D, Tatebayashi, M, Besen, G, Amani, R, Wiley, C A, Vuong, C, Aldern, K A
Format: Artigo
Jezik:Inglês
Izdano: 1995
Teme:
Research Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC162748/
https://ncbi.nlm.nih.gov/pubmed/7574537
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