Herpes simplex virus ribonucleotide reductase mutants are hypersensitive to acyclovir.

Two mutants defective in herpes simplex virus-encoded ribonucleotide reductase activity exhibited the novel phenotype of hypersensitivity to acyclovir, aphidicolin, and to a lesser extent, phosphonoacetic acid. These results have implications for acyclovir resistance and the development of drugs tha...

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Detalhes bibliográficos

Publicado no:	Antimicrob Agents Chemother
Principais autores:	Coen, D M, Goldstein, D J, Weller, S K
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1989
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC172665/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2552912/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.33.8.1395
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