Novel mutations in reverse transcriptase of human immunodeficiency virus type 1 reduce susceptibility to foscarnet in laboratory and clinical isolates.

Foscarnet (phosphonoformic acid) is a pyrophosphate analog that inhibits the replication of human immunodeficiency virus type 1 (HIV-1) in vitro and in patients with AIDS. HIV-1 resistance to foscarnet has not been reported despite long-term foscarnet therapy of AIDS patients with cytomegalovirus di...

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Detalhes bibliográficos

Publicado no:	Antimicrob Agents Chemother
Principais autores:	Mellors, J W, Bazmi, H Z, Schinazi, R F, Roy, B M, Hsiou, Y, Arnold, E, Weir, J, Mayers, D L
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1995
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC162688/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7542860/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.39.5.1087
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