Novel mutations in reverse transcriptase of human immunodeficiency virus type 1 reduce susceptibility to foscarnet in laboratory and clinical isolates.

Foscarnet (phosphonoformic acid) is a pyrophosphate analog that inhibits the replication of human immunodeficiency virus type 1 (HIV-1) in vitro and in patients with AIDS. HIV-1 resistance to foscarnet has not been reported despite long-term foscarnet therapy of AIDS patients with cytomegalovirus di...

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Enregistré dans:
Détails bibliographiques
Auteurs principaux: Mellors, J W, Bazmi, H Z, Schinazi, R F, Roy, B M, Hsiou, Y, Arnold, E, Weir, J, Mayers, D L
Format: Artigo
Langue:Inglês
Publié: 1995
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC162688/
https://ncbi.nlm.nih.gov/pubmed/7542860
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