Effects of Specific Zidovudine Resistance Mutations and Substrate Structure on Nucleotide-Dependent Primer Unblocking by Human Immunodeficiency Virus Type 1 Reverse Transcriptase

Nucleotide-dependent unblocking of chain-terminated DNA by human immunodeficiency virus type 1 reverse transcriptase (RT) is enhanced by the presence of mutations associated with 3′-azido-3′-deoxythymidine (AZT) resistance. The increase in unblocking activity was greater for mutant combinations asso...

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Detalhes bibliográficos
Main Authors: Meyer, Peter R., Matsuura, Suzanne E., Tolun, Adviye A., Pfeifer, Ingrid, So, Antero G., Mellors, John W., Scott, Walter A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2002
Assuntos:
Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC127181/
https://ncbi.nlm.nih.gov/pubmed/11959594
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.46.5.1540-1545.2002
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