Differential Removal of Thymidine Nucleotide Analogues from Blocked DNA Chains by Human Immunodeficiency Virus Reverse Transcriptase in the Presence of Physiological Concentrations of 2′-Deoxynucleoside Triphosphates

Removal of 2′,3′-didehydro-3′-deoxythymidine-5′-monophosphate (d4TMP) from a blocked DNA chain can occur through transfer of the chain-terminating residue to a nucleotide acceptor by human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT). ATP-dependent removal of either d4TMP or 3′-a...

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Detalhes bibliográficos

Publicado no:	Antimicrob Agents Chemother
Principais autores:	Meyer, Peter R., Matsuura, Suzanne E., Schinazi, Raymond F., So, Antero G., Scott, Walter A.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 2000
Assuntos:	Antiviral Agents
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC90226/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11083661/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.44.12.3465-3472.2000
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