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Optimized Method for the Synthesis of Alkyne-Modified 2′-Deoxynucleoside Triphosphates

A general approach is presented for synthesizing alkyne-modified nucleoside triphosphates via the Sonogashira cross-coupling reaction of unprotected halogenated 2ʹ-deoxynucleoside, followed by monophosphorylation and the reaction of the corresponding phosphoromorpholidate with tributylammonium pyrop...

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Autores principales: Viktoriya E. Kuznetsova, Valeriy E. Shershov, Georgiy F. Shtylev, Ivan Yu. Shishkin, Veronika I. Butvilovskaya, Andrey A. Stomakhin, Irina V. Grechishnikova, Olga A. Zasedateleva, Alexander V. Chudinov
Formato: Artigo
Lenguaje:Inglês
Publicado: MDPI AG 2024-10-01
Colección:Molecules
Materias:
modified nucleoside triphosphate
Sonogashira coupling
phosphoromorpholidate
phosphorylation
primer extension
Acceso en línea:https://www.mdpi.com/1420-3049/29/19/4747
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