The matrix protein CCN1 (CYR61) induces apoptosis in fibroblasts

Integrin-mediated cell adhesion to extracellular matrix proteins is known to promote cell survival, whereas detachment from the matrix can cause rapid apoptotic death in some cell types. Contrary to this paradigm, we show that fibroblast adhesion to the angiogenic matrix protein CCN1 (CYR61) induces...

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Bibliographic Details
Main Authors: Todorovicç, Viktor, Chen, Chih-Chiun, Hay, Nissim, Lau, Lester F.
Format: Artigo
Language:Inglês
Published: The Rockefeller University Press 2005
Subjects:
Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1626352/
https://ncbi.nlm.nih.gov/pubmed/16275757
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200504015
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